Aging Phenomena: Relationships among Different Levels of by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki,

By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

The challenge of senescence, as mirrored within the background of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. by contrast, gerontology as a department of technology continues to be relatively younger. in the past decade, concomitant with swift development in our realizing of the fundamental lifestyles sciences, titanic shops of information approximately organic getting older were gathered. this information, even though, bobbing up from many medical disciplines and involved in various degrees of biologic association, turns out virtually random and covers every thing from molecules to human societies. Theories complex to interpret the proof and to appreciate the mech­ anisms fascinated by senescence have remained in person, instead of basic, territories. It has lengthy been felt through a few gerontologists that it was once time for a number of the experts to step again and take a generalist view of gerontology, to think again and reevaluate the culmination in their analyt­ ical goals at diverse degrees inside a broader context. a few others might imagine it nonetheless untimely. It appeared, even though, that almost all of these who accumulated in Tokyo at the celebration of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be won in trying to find interrelationships one of the evidence and theories originated within the diverse degrees of investiga­ tion in an try to detect and relish the organic drama of senescence as an entity.

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235:274 (1960). H. C. Robinson, The sulfation of chondroitin sulfate in embryonic chicken cartilage, Biochem. J. 113:543 (1969). S. DeLuca, M. E. Richmond, and J. E Silbert, Biosynthesis of chondroitin sulfate: Sulfation of the polysaccharide chain, Biochemistry 12:3911 (1973). G. W. Hart, Glycosaminoglycan sulfotransferases of the developing chick cornea, J. Biol Chem. 253:347 (1978). H. Saito, T. Yamagata, and S. Suzuki, Enzymatic methods for the determination of small quantitites of isomeric chondroitin sulfates, J.

This means that rat costal cartilage is suitable for examining the influence of aging on the biosynthesis of chondroitin sulfate. Age-Dependent Alteration in the Biosynthetic Activities of Cartilage In an attempt to determine the cause of an age-dependent alteration in the tissue contents of GAG, we examined the influence of aging on the biosynthetic activity of cartilage in the production of hexosamine-containing sUbstances. , glycosaminoglycan (GAG) and glycopeptide (GP), were prepared and analyzed.

Geriat. 13:157, 1976. T. Makinodan and W. Adler, The effects of aging on the differentiation and proliferation potentials of cells of the immune system, Fed. Proc. 34:153, 1975. MULTINUCLEATION AND POLYPLOIDIZATION OF AGING HUMAN CELLS IN CULTURE Toshiharu Matsumura Department of Cancer Cell Research Institute of Medical Science University of Tokyo Shirokanedai, Minato-ku Tokyo 108, Japan INTRODUCTION Multinucleated cells and polyploid cells appear widely in liver, salivary glands, and other mammalian organs.

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