Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis

By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between quite a few human pathogenic microorganisms comparable to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as essentially the most vital medical demanding situations of this century. elevated normal expertise and worry of those pathogens capability there's a becoming call for for examine to take on the specter of multidrug resistance. Documenting the newest examine within the box, this booklet discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and structures microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.

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