By Peter Tomasulo M.D. (auth.), R. M. Winslow, K. D. Vandegriff, M. Intaglietta (eds.)
This quantity features a choice of essays via chosen authors who're energetic within the box of blood substitutes study or heavily allied disciplines. those essays have been added as lectures through the authors on the moment annual "Current concerns in Blood replacement examine and improvement - 1995" path backed together by way of the Departments of medication and Bioengineer ing, college of California, San Diego, the nationwide Institutes of wellbeing and fitness (NHLBI), and the U.S. military on March 30, 31, and April 1, 1995 in San Diego. This path had 3 pursuits: to provide fundaniental discussions of clinical concerns serious to additional improvement of man-made oxygen providers, to supply academicians a discussion board to debate their present study, and to supply the corporations considering constructing items the chance to replace the viewers on their development. The association owes a lot to the solicited reviews of the attendees of the 1994 direction. we wish particularly to thank the U.S. military, really in the course of the efforts of COL John Hess, who supplied major investment to make booklet of this quantity attainable. additionally, a few of the partaking businesses supplied extra monetary aid to offset the prices of the direction. those comprise Alliance Pharmaceutical Corp., Hemosol, Nippon Oil and fats, Northfield Laboratories, and Ortho Biotech.
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Extra resources for Blood Substitutes: Physiological Basis of Efficacy
Transfusion 23: 416(abstract), 1983. E. G. Coleman. Cardiac Output and Its Regulation. 2 nd edition. Philadelphia: Saunders, 1973. , T. F. Laterre, A. Dougnac, J. S. Reynaert. Significance of pathologic oxygen supply dependency in critically ill patients: comparison between measured and calculated methods. Intensive Care Med. 20: 12-18, 1994. , A. Rosen, L. Sehgal, S. Gould, H. Sehgal, and G. Moss. Physiologic effects of acute anemia: implications for a reduced transfusion trigger. Transfusion 30: 11-141990.
8: 7-11, 1992. L. Simon. The red blood cell transfusion trigger. Physiology and clinical studies. Arch. Pathol. Lab. Med. 118: 429-344, 1994. D. Petz. Clinical Practice of Transfusion. 2 nd Edition. Churchill Livingstone, pp. 531-548, 1989. Tomasulo, P •. World-wide blood supply and its impact on development of blood substitutes. M. Winslow, K. D. Vandegriff, and M. ) Boston: Birkhauser, 1995, pp. 1-19. D. Diffusion and chemical reaction in pulmonary gas exchange. Physiol. Rev. 57: 257-312, 1977.
This is actually the red cell 2,3-DPGlhemoglobin molar ratio. 88 mole/mole (Samaja and Winslow 1979). The 2,3DPGIHb ratio, pH, and PC0 2 are the principle determinants of the position of the blood 02-dissociation curve (P50). These parameters are used 29 A Physiologic Basis for the Transfusion Trigger to calculate a continuous curve for the given conditions used in the example calculations (Winslow et al. 1983). 2 Graphical representation of the Fick equation. The examples are described in the text and include normal resting conditions (top), anemia (middle), and increased 02 demand (bottom) as in mild to moderate exercise.