By Magda Esebua (auth.), Heide Schatten (eds.)
Highlighting contemporary advances in our realizing of breast melanoma, this booklet is meant for a large viewers as a reference publication. integrated are stories of genetics, epigenetics, quite a few features of mobile and molecular biology, and several components of breast melanoma which are geared toward picking new intervention websites for remedies and treatments of the illness. The chapters are written via the world over well-known specialists and contain reports of key subject matters in breast melanoma examine. every one bankruptcy highlights the recent points of particular examine subject matters and many of the affects of designing new techniques in addition to identifies new objectives for healing intervention. the themes addressed are chosen to be of curiosity to sufferers, scientists, scholars, academics, and an individual else attracted to increasing their wisdom of breast melanoma imaging, diagnostics, therapeutics, or easy biomedical study on breast cancer.
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Additional info for Cell and Molecular Biology of Breast Cancer
7 F. Buggi et al. Future Perspectives: Biological Determinants of Aggressiveness The sensitivity of some breast cancers to hormones and the possibility of reducing the growth of these tumors by removal of circulating estrogens have been known for over 100 years; quantitatively, it is reported that 50–80 % of breast cancers are ER positive, thus hormone therapy has possibly prognostic relevance for a significant proportion of patients . However, as mentioned above, in cases of multiple breast cancer current guidelines recommend that the highest T category tumor should be the one selected for classification and staging.
DNA analysis of ductal carcinoma in situ of the breast. A comparison with histologic features. Cancer. 1991;68:2602. 24. van de Vijver MJ, Peterse JL, Mooi WJ, et al. Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med. 1988;319:1239. 25. Bartkova J, Barnes DM, Millis RR, Gullick WJ. Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ. Hum Pathol.
Chapter 2 Multicentric/Multifocal Breast Cancer: Overview, Biology, and Therapy Federico Buggi, Annalisa Curcio, Fabio Falcini, and Secondo Folli Abstract Multiple breast cancers may present with different clinical and biological characteristics as compared with unicentric disease, and in certain instances this may have implications as far as treatment is concerned. Multiple tumors may have increased lymph node involvement compared with unifocal tumors, and some available data suggest that multifocal/multicentric breast cancer is actually more aggressive and carries worse overall outcomes than unifocal disease.