Characterization of Protein Therapeutics using Mass by Ismael Cotte-Rodriguez, Zhixin Miao (auth.), Guodong Chen

By Ismael Cotte-Rodriguez, Zhixin Miao (auth.), Guodong Chen (eds.)

This publication highlights present ways and destiny tendencies within the use of mass spectrometry to signify protein cures. As the most usually applied analytical innovations in pharmaceutical study and improvement, mass spectrometry has been common within the characterization of protein therapeutics as a result of its analytical sensitivity, selectivity, and specificity. This publication starts with an outline of mass spectrometry options as relating to the research of protein therapeutics, structural id options, quantitative methods, by means of reviews regarding characterization of procedure comparable protein drug impurities/degradants, metabolites, greater order buildings of protein therapeutics. either common practitioners in pharmaceutical learn and experts in analytical sciences will reap the benefits of this e-book that information step by step methods and new thoughts to unravel tough difficulties concerning protein therapeutics study and development.

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Chen H, Ouyang Z, Cooks RG (2006) Thermal production and reactions of organic ions at atmospheric pressure. Ford MJ, Van Berkel GJ (2004) An improved thin-layer chromatography/mass spectrometry coupling using a surface sampling probe electrospray ion trap system. Shieh IF, Lee CY, Shiea J (2005) Eliminating the interferences from TRIS Buffer and SDS in protein analysis by fused-droplet electrospray ionization mass spectrometry. Andrade FJ, Shelley JT, Wetzel WC et al (2008) Atmospheric pressure chemical ionization source.

Miao Z, Wu S, Chen H (2010) The study of protein conformation in solution via direct sampling by desorption electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 21:1730–1736 46 I. Cotte-Rodriguez et al. Yang SH, Wijeratne AB, Li L, Edwards BL, Schug KA (2011) Manipulation of protein charge states through continuous flow-extractive desorption electrospray ionization: a new ambient ionization technique. Cotte-Rodriguez I, Takats Z, Talaty N et al (2005) Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization.

12 Photodissociation in a quadrupole ion trap [250]. 1 eV for a typical CO2 laser), allowing multiple photons to be absorbed to promote dissociation [250, 254]. The photons used in IRMPD may originate from a laser with wavelengths in the infrared range, or from the blackbody irradiation, which is called blackbody infrared radiative dissociation (BIRD) [255]. CO2 laser is the most popular choice for IRMPD since it is widely available and affordable. 6 μm) can be absorbed by a large amount of organic molecules [250].

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