Cytokeratins in Intracranial and Intraspinal Tissues by Dr. rer. nat. habil Michael Kasper (auth.)

By Dr. rer. nat. habil Michael Kasper (auth.)

This ebook summarises present immunomorphological facts of cytokeratin detection within the quite a few telephone different types of intracranial and intraspinal tissues.The methodical difficulties in their detection are mentioned in addition to the interspecies variability within the expression of intermediate filaments. including the microtubuli and the microfilaments, intermediate filament proteins characterize the most parts of the vertebrate mobilephone cytoskeleton. The evaluation in particular makes a speciality of the main up to date fabric relating cytokeratin expression inselected neutoectodermal tissues, for which merely sparse effects exist. crucial details at the most modern findings during this box coupled with new experimental information through the writer are supplied during this quantity. Chapters assessment methodical features and difficulties within the evaluate of filament proteins via immunocytochemistry and discover the connection of cytokeratin expression to mobile differentiation. additionally mentioned are: functionality of intermediate filaments; species alterations within the expression in the course of ontogeny; and pathologic alteration of tissues and tumor improvement.

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T. t. t. t. + + + Adult pituitary gland endocrine cells(n = 2) + + + +/- + + + + + +/- + _/+c +/+/- + + + "12th week of gestation. , pancreas acinus cells, were stained by this antibody. C Only a subpopulation of endocrine cells in the pars intermedia was positive. , not tested. antibodies were generated from human cytokeratin preparations or cell lines and their reactions with animal cytokeratins may deviate from those with human cytokeratins. Our latest investigations of human tissues using the same antibodies demonstrated a more or less homogeneous tissue reactivity with ectodermal and neuroectodermal cytokeratins (Table 9).

1984; Nakajima et al. 1980; Velasco et al. 1982) . Cytokeratin was first demonstrated in the folliculostellate cell of human adenohypophysis by Tachibana and Yamashima (1988). Only a small number of cells, however, were doublelabeled with GFAP and cytokeratin. Mainly two types of folliculostellate cells were disclosed: GFAP-positive cells which might be neuroectodermal or glial in origin and cytokeratin-positive cells which might be derived from the stomodeum. Our own, independent study using individual cytokeratin polypeptide-specific antibodies characterized the folliculostellate cell as a predominantly cytokeratin-vimentin-, and to a lesser extent GFAP-expressing cell type in humans.

T. t. t. t. t. t. Broadly specific antibody A43B/B3. t. not tested; +, positive; -, negative; -1+, single cells positive. a Table 11. Cytokeratin expression in meningiomas Reference No. Remarks Holden et al. 1987 Kepes 1986 Meiss et al. 1986 Theaker et al. 1986 Terpe et al. 1988 Budka 1986 14 50 13 43 1 Ng et al. 1987 29 Mennel et al. 1989 Radley et al. 1989 Vakili and Muller 1988 1 25 3 Schnitt and Vogel 1986 22 5 cytokeratin-positive No details given 12 cytokeratin-positive 5 cytokeratin-positive 9 cytokeratin-8- and 18-positive One case with triple expression of cytokeratin, GFAP, vimentin 2 secretory meningiomas cytokeratin-positive Cytokeratin in hyaline inclusions 32% positive for cytokeratins Meningotheliomatous meningiomas with hyaline inclusions or pseudopsammoma bodies were studied 1 meningioma with cytokeratinpositive cell clusters data about strong cytokeratin staining of fetal human meninges in the brain (Stagaard and Mollgard 1989).

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