Epigenetic Regulation of Lymphocyte Development by Sven Heinz, Christopher K. Glass (auth.), Cornelis Murre

By Sven Heinz, Christopher K. Glass (auth.), Cornelis Murre (eds.)

The reports defined during this quantity function a place to begin to familiarize one self with the multifarious transformations in epigenetic designs that orchestrate the development of constructing blood cells. additionally they may possibly function a normal paradigm for the mechanisms that underpin the regulate of eukaryotic gene expression.

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Nat Immunol 9:927–936 Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, Cezard T, Fejes AP, Wederell ED, Cullum R, Euskirchen G, Krzywinski M, Birol I, Snyder M, Hoodless PA, Hirst M, Marra MA, Jones SJ (2008) Genome-wide relationship between histone H3 lysine 4 mono- and trimethylation and transcription factor binding. Genome Res 18:1906–1917 Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R (2007) Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 31:576–586 Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K (2009) PI3 kinase signals BCR-dependent mature B cell survival. Cell 139:573–586 Thal M, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA (2009) Ebf1-mediated downregulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci USA 106:552–557 Travis A, Hagman J, Grosschedl R (1991) Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factorbinding sites and initiation site sequences.

One of the proteins encoded by Tcfe2a, E12, drives B cell development in Tcfe2a-/- MPPs (Bhalla et al. 2008). A consequence of E12 expression is the restoration of EBF1 expression, which is lost in the absence of E2A. These activities of E2A proteins, together with co-occupancy of regulatory modules with EBF1, suggest the importance of functional collaborations between the two factors in B lymphopoiesis. 1 EBF1 and the Basis of B Lineage Fate Decisions Many studies have implicated EBF1 as a primary determinant of B cell lineage specification.

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