G-Functions and Geometry: A Publication of the by Yves Andre

By Yves Andre

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Extra info for G-Functions and Geometry: A Publication of the Max-Planck-Institut Fur Mathematik (Aspects of Mathematics. E, V. 13.)

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It should be emphasized that the array of structures listed in Table 1 are but a point of departure. The competition dialysis method is completely general, and arrays of structures of particular interest can be designed as desired. The only limitations are that the structures be large enough to be retained by the dialysis tubing chosen for use, and that they are verified to be stable under the ionic conditions of the experiment. Essential quality control experiments to characterize nucleic acid samples were described in detail [41, 42] and include UV absorbance and circular dichroism spectroscopy, and thermal denaturation studies.

Fig. 1 Schematic of the competition dialysis experiment. A schematic representation of the structures used is shown on the left. The center shows the simple experimental setup, a beaker containing the test ligand solution and the holder for the dialysis units. A schematic of the microdialysis unit is shown on the right Structural Selectivity of Drug-Nucleic Acid Interactions 37 The competition dialysis assay described here [32] is a simple and straightforward extension of Crothers’ original method.

35 35 37 38 39 41 3 Global Analysis of the Data from the First Generation Assay . . . . . . 1 Trends from Tukey Box Plots . . . . . . . . . . . . . . 2 New Metrics: the Specificity Sum (SS) and SS/Cmax . . . . . . . . 42 42 45 4 Quantitative Analysis of Competition Dialysis Data: Validation . . . . . 49 5 Summary and Outlook . . . . . . . . . . . . . . . . 50 . . . . . . . . . . . . . . . . . . . . 51 References . . . . . .

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