GTPases in Biology I by H. R. Bourne (auth.), Professor Burton F. Dickey M.D.,

By H. R. Bourne (auth.), Professor Burton F. Dickey M.D., Professor Lutz Birnbaumer Ph.D. (eds.)

Recent advances in molecular biology have proven GTPases and phosphoproteins to be the paramount molecular switches applied intracellularly in organic platforms. The origins of the GTPase swap seem to be virtually as historic as lifestyles itself, and during evolution nature has tailored this swap to various reasons. during this two-volume paintings a wide survey of the main sessions of GTPases is gifted. The function of GTPases in making sure accuracy in the course of protein translation, a brand new examine the trimeric G-protein cycle, the molecular functionality of ARF in vesicle coating, the rising position of the dynamin family members in vesicle move, GTPases which turn on GTPases in the course of nascent protein translocation, and the numerous roles of ras-related proteins in progress, cytoskeletal polymerization, and vesicle move, are all defined in eighty chapters by way of the top specialists of their fields. either precise wisdom of particular structures or proteins and normal rules of constitution and serve as are provided. a lot of this knowledge hasn't ever been released ahead of. on the cost the of GTPases is growing to be it turns into more and more not likely that we are going to back get it to sit down for a bunch portrait equivalent to this. as a result, the amount has the opportunity to develop into the reference paintings for GTPases.

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E. Downstream Functions of rho-Like Proteins. . . . . . . . . . 1. Mammalian rho Proteins . . . . . . . . . . . . . . . . II. The rac Proteins ....................................... 1. rac and the Actin Cytoskeleton . . . . . . . . . . . . 2. rac and the Superoxide Production. . . . . . . . . . . 3. Other rho-Related Proteins. . . . . . . . . . . . . . F. Conclusions ..............................................

E. Function of p21 ras in T Lymphocytes. . . . . . . . . . . . . References. . . . . . . . . . . . . . . . . . . . . . . . . . W. D. GOMPERTS. With 7 Figures A. GTP: A Sine Qua Non for Exocytosis . . . . . . . . . . . . I. Ca2+-Dependent Secretion in Myeloid Granulocytes. . . . . B. Probing Exocytosis: Permeabilised Cells. . . . . . . . . . . I. GTPyS-Induced, Ca2+ -Independent Exocytosis . . .

D. HOUSLAY . . . . . . . . . . . . . . . . . . . . . . . . 147 CHAPTER 54 Receptor to Effector Signaling Through G-Proteins: P"I Dimers Join a Subunits in the World of Higher Eukaryotes L. BIRNBAUMER . . . . . . . . . . . . . . . . . . . . . . . . 167 D. T. PREMONT, J. CHEN, O. JACOBOWITZ, and R. IYENGAR. . . . . G. WENSEL ................................................ 213 Contents of Campanion Volume 1081II XLI CHAPTER 57 High-Voltage Activated Ca2+ Channel F.

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