Health effects of polyunsaturated fatty acids in seafoods by Artemis P Simopoulos; Robert R Kifer; Roy E Martin; National

By Artemis P Simopoulos; Robert R Kifer; Roy E Martin; National Institutes of Health (U.S.). Nutrition Coordinating Committee.; National Fisheries Institute

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It t h e r e f o r e s e e m s likely t h a t s o m e further a l t e r a t i o n in t h e diet in t e r m s o f d o s e a n d t i m e w o u l d b e r e q u i e d to a c h i e v e b i o l o g i c d o w n r e g u l a t i o n o f t h e m o n o c y t e . T h i s is v e r y i m p o r t a n t in v i e w o f t h e role o f t h e m o n o c y t e in the maintenance of subacute and chronic tissue injury of both immunologic a n d n o n - i m m u n o l o g i c origin. T h e studies of Goetzl and colleagues in the asthmatic population are s o m e w h a t complicated by the simultaneous administration of steroids, but t h e y did r e v e a l a m a r k e d i n c r e a s e in t h e m i t o g e n i c r e s p o n s e to p h y t o h e m a g g l u t i n i n .

It is clear that t h e i s s u e o f t h e rate o f delta-4 desatu r a t i o n in h u m a n t i s s u e n e e d s m u c h a t t e n t i o n , particularly w i t h r e s p e c t to 22:6ω3 f o r m a t i o n . T h e availability o f relatively large q u a n t i t i e s o f d e u t e r a t e d 18:3ω3 a n d 22:6ω3 w o u l d p e r m i t t h e e v a l u a t i o n o f t h e relative c o n t r i b u t i o n s o f t h e s e t w o dietary fatty a c i d s to t i s s u e c o m p o n e n t s . O n e c o u l d feed e q u i m o l a r 6 12 a m o u n t s o f d -18:3o)3 a n d d -22:6co3 to a p e r s o n for a c o n s i d e r a b l e p e r i o d of t i m e so as to a l l o w equilibration w i t h t i s s u e lipids.

Phillipson BE, Rothrock DW, Connor W E , Harris WS, and Illingworth DR. (1985). Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. Ν Engl J Med 322:1210. 1. Historical Perspective, Conclusions and Recommendations, and Actions 29 17. Karmali RA, Marsh J, Fuchs C. (1984). Effect of omega - 3 fatty acids on growth of a rat mammary tumor. JNCI 73Ά57. 18. Connor WE. (1985). -Japan Cooperative Medical Sciences Program, Bethesda, Maryland, July 15-17, 1985.

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