Immunological Surveillance by Macfarlane Burnet

By Macfarlane Burnet

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The part played by the 3 V segment of the heavy chain must await the accumulation of data. Three years ago I suggested (Burnet, 1966) that 3V was identical with IV in any given Ig G molecule. What little evidence there is, seems to be against this but examination of the first half dozen residues of H and L chains in a shark immunoglobulin by Suran and Papermaster (1967) is in agreement. The possibility that the IV and 3V segments must be homologous but not necessarily identical would also cover most of the points made in the 1966 paper and this seems to be in line with the recent findings of Gottlieb et al (1968) who compared the sequences of the variable segments in light and heavy chain from the same myeloma protein.

Third, where functional activities are measurable the activity of the hybrid is usually intermediate between that of the parental forms. 6 x 10-5 · There is much less evidence for somatic hybridization with segregation of qualities and return to the diploid 2n quality in the recombinant. Stone and Irwin (1966) describe a chimeric pair of cattle twins in which two different antigenic types of cell were present. Both showed 90% of the type appropriate to calf A and 10% of that proper to calf B. This was constant for at least three years.

LogAog. plot of specific age incidence of death from malignant disease in Australia. ) Introductory Conspectus 27 before the irreversible commitment to malignancy occurred and in which at least one of the pre-critical mutations endowed a proliferative advantage on the resulting clone. I shall take the point of view that ageing represents to a large extent the accumulation of somatic cell inefficiencies and anomalies as a result of somatic mutation not necessarily or usually associated with a proliferative advantage.

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