Leukocyte Typing II: Volume 2 Human B Lymphocytes by Lee M. Nadler (auth.), Ellis L. Reinherz MD, Barton F.

By Lee M. Nadler (auth.), Ellis L. Reinherz MD, Barton F. Haynes MD, Lee M. Nadler MD, Irwin D. Bernstien MD (eds.)

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These activation antigens appear to be very interesting and are very likely candidates for clusters in the next Workshop. Finally, the three antibodies B13 (SJ12-3G2), B20 (PC-1), and B32 (9BA-5) also appear to be B lineage restricted. The molecular nature of these antigens is unknown. 20). Very little can be said about these antigens from the studies undertaken in this Workshop. These antigens may be expressed on very discrete stages of B cell differentiation or alternatively on minor B cell populations.

These antibodies define a B lineage-restricted antigen since their expression within the hematopoietic system is limited to normal and neoplastic B cells. 11). In contrast, CD 19 antigen is expressed on fewer than 5% of bone marrow mononuclear cells. The CD19 antigen was not detected on peripheral blood T cells, monocytes, or granulocytes. 11). The specificity and expression of the CD19 antigen in B cell ontogeny is further confirmed by its expression on cell lines. The CD19 antigen is expressed on all pre-B cell, B-lymphoblastoid, and Burkitt's lymphoma cell lines and on two of the four myeloma cell lines tested.

Finally, the CD22 antigen was not expressed on those myelomas tested. Although not expressed on any T cell leukemias or lymphomas, a small number of AMLs occasionally demonstrated reactivity with the CD22 antibodies. The reactivity did not appear to be consistently expressed on germinal center B cells whereas some felt that germinal center B cells were negative. The antigen did not react with dendritic reticulum cells and therefore was clearly B lineage restricted. Activation of resting B cells with mitogens led to the rapid loss of the CD22 antigen (this volume, Chapter 37).

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