Lung Biology in Health & Disease Volume 201 Lung Surfactant by Kaushik Nag

By Kaushik Nag

The single resource to explain the lung surfactant as a fancy membranous approach, this advisor analyzes lung surfactant functionality from the facets of molecular biology, biophysics, membrane technology, and floor and interface research and stories the most recent uncomplicated and medical matters on the subject of lung ailment and (dys)function.

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Postle AD, Al MD, Burdge GC, Hornstra G. The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy. Early Hum Dev 1995; 43:47 –58. Seeger W, Gu¨nther A, Walmrath HD, Grimminger F, Lasch HG. Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects. Clin Invest 1993; 71:177 – 190. Hartog A, Gommers D, Lachmann B. Role of surfactant in the pathophysiology of the acute respiratory distress syndrome (ARDS). Monaldi Arch Chest Dis 1995; 50:372– 377.

Content of dipalmitoyl phosphatidylcholine in lung surfactant: ramifications for surface activity. Pediatr Res 1996; 39:805– 811. Postle AD, Heeley EL, Wilton DC. A comparison of the molecular species compositions of mammalian lung surfactant phospholipids. Comp Biochem Physiol A Mol Integr Physiol 2001; 129:65 – 73. Mander A, Langton-Hewer S, Bernhard W, Warner JO, Postle AD. Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections.

Daniels et al. (52) demonstrated that increasing body temperature from 278C to 378C in central netted dragons, Ctenophorus nuchalis, decreases the opening pressure of the lungs without affecting lung compliance. This may reflect an increase in fluidity due to the increase in temperature and thus, an increase in the spreadability of surfactant over alveolar surfaces at 378C (52). In bearded dragons, Pogona vitticeps, increasing body temperature from 188C to 378C had no effect on opening pressure or filling pressure (60).

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