Membrane Transporters: Methods and Protocols (Methods in by Qing Yan (Editor)

By Qing Yan (Editor)

This choice of state-of-the-art methodologies for learning membrane transporters and channels takes good thing about the entire most up-to-date advancements in biomedical learn, together with pharmacogenomcs, bioinformatics, and microarray applied sciences. The authors clarify databases and instruments for bioinformatics experiences, offer functional directions for microarray experiments and information research, and illustrate using small attitude X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to review the structural biology of membrane transporters. equipment for exploring structure-function correlation, akin to site-directed mutagenesis, immunocytochemistry, and confocal microcopy also are defined, in addition to a number of that could assist in the advance of novel therapeutics.

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G. and von Heijne, G. (1994) TopPred II: An improved software for membrane protein structure predictions. CABIOS 10, 685–686. 12. Saier, M. , Jr. and Kollman J. (1999) Is FatP a long chain fatty acid transporter? Mol. Microbiol. 33, 670–672. 36 Busch and Saier 13. Faergeman, N. , Black, P. , Zhao, X. , et al. (2001) The acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular utilization.

Linton, K. , et al. (2000) Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum. Mol. Genet. 9, 1209–1217. 62. , et al. (1993) Abnormal messenger RNA expression and a missense mutation in patients with X-linked adrenoleukodystrophy. Hum. Mol. Genet. 2, 1949–1951. 63. Krasemann, E. , Korenke, G. , et al. (1996) Identification of mutations in the ALD-gene of 20 families with adrenoleukodystrophy/ adrenomyeloneuropathy.

1. A. A usually consist of bundles of transmembrane α-helices that form α-helical aqueous pores or channels. Rarely, β-strands contribute to the channel. These channels are found ubiquitously in the membranes of all types of organism. 2. B. C proteins consist exclusively of β-strands that form β-barrels. These channels are found in the outer membranes of bacteria, mitochondria, and plastids. 3. C. C attack target cells other than the producer cell by inserting into the target cell membrane, usually forming oligomeric transmembrane pores.

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