Methods for NEURAL ENSEMBLE RECORDINGS by Miguel A. L. Nicolelis

By Miguel A. L. Nicolelis

Neuroscientists have lengthy famous the significance of realizing the underlying ideas of knowledge processing via huge populations of neurons. tools for Neural Ensemble Recordings explores equipment for utilizing electrophysiological strategies for tracking the concurrent task of ensembles of unmarried neurons. given that present tools enable one to at the same time checklist the extracellular task of as much as 100-150 neurons for days or weeks, neural ensemble recordings were used to deal with long-standing concerns in improvement, studying, reminiscence, sensorimotor integration, sensory details processing, and neuronal plasticity.

EXAMINES the numerous attainable purposes FOR THIS innovative METHOD

Each bankruptcy bargains a step by step description for the implementation of a selected approach or experimental paradigm using simultaneous a number of electrode recordings. The ideas defined can be utilized in functions that impression a wide workforce of existence scientists, including:

  • drug screening (pharmacology) in either in vitro and in vivo preparations
  • developmental stories and experiences of neuronal plasticity
  • chronic tracking of neuronal functionality in behavioral studies
  • physiological tracking of neuronal job in cellphone cultures and mind slices
  • physiological tracking of neuronal task in neurons trafected with genetic vectors
  • chronic tracking of physiological adjustments in populations of neurons in the course of studying of latest sensorimotor and cognitive tasks
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    Additional info for Methods for NEURAL ENSEMBLE RECORDINGS

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    Two examples of two-dimensional arrays. C. A three-dimensional array. D. A multidimensional array. within the brain and lowered during surgery at various angles to ensure proper placement in the brain area of interest or avoid trouble spots such as the ventricles. In addition to straight, individual microwires bundled together, tetrodes44 or stereotrodes45 have been used to separate neurons whose action potentials have very similar amplitudes or neurons that burst with action potentials of varying amplitude.

    Dynamics of the hippocampal ensemble code for space, Science, 261, 1055, 1996. 31. Wilson, M. , McNaughton, B. , Reactivation of hippocampal ensemble memories during sleep, Science, 265, 6761, 1996. 32. Nicolelis, M. A. , Lin, R. C. , Woodward, D. , Chapin, J. , Dynamic and distributed properties of many-neuron ensembles in the ventral posterior medial thalamus of awake rats, Proc. Natl. Acad.

    For instance, the deeper the brain structure that you are recording from, the less important it is to keep the dura intact. Moreover, it is also difficult to insert electrodes through the dura since most multiple-site recording electrodes bend at the dura surface. Users of this technology have devised several ways around this dilemma, depending on the type of electrode used (see Chapters 5 and 7). Microwires can sometimes “pop” through the dura when driven very quickly. However, this may cause damage just below the dura.

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