Molecular Biology of G-Protein-Coupled Receptors by Nicholas J. P. Ryba, Matthew D. Hall (auth.), Mark R. Brann

By Nicholas J. P. Ryba, Matthew D. Hall (auth.), Mark R. Brann (eds.)

LESLIE L. IVERSEN the current sequence of volumes is definitely timed, because the effect of molecular genetics on pharmacology has been profound, and a entire evaluate of the quick advances of the earlier decade is far wanted. because the pioneering paintings of Dale, Ariens, and others within the early years of this century, a lot of pharmacology has been based at the suggestion of receptors. to start with, the receptor was once conceived of as a "black box," which well-known and transduced the organic results of neurotransmit­ ters, hormones, or different organic messengers-and which may additionally signify a goal for man-made medications. it is just within the final 20 years that "molecular pharmacology" has blossomed, first with the arrival of radioligand binding ideas and moment messenger stories which enormously facilitated the biochemical research of drug-receptor interactions, and latterly with expanding wisdom of the molecular structure of the receptor proteins themselves. This begun with the conventional biochemical procedure of separating and purifying the receptor molecules. This proved to be a role of monstrous technical trouble due to the low density of receptors in such a lot organic resource tissues, even though there have been a few remarkable successes, e. g. , the purification of the nicotinic acetylcholine receptor from the electrical organ of Torpedo. It used to be the ap­ plication of molecular genetics know-how throughout the Eighties, in spite of the fact that, which particularly sped up development during this field.

Show description

Read Online or Download Molecular Biology of G-Protein-Coupled Receptors PDF

Similar biology books

Receptor Binding Techniques

Protecting the excessive criteria set by way of the winning first version, Anthony P. Davenport and a panel of hands-on researchers from the pharmaceutical and academia reap the benefits of the newest advancements to supply designated useful equipment for learning receptors in silico, in vitro, and in vivo.

Angiogenesis: In Vitro Systems Part A

Angiogenesis is the expansion of recent blood vessels and is a vital ordinary technique within the physique. A fit physique keeps an ideal stability of angiogenesis modulators. in lots of critical illness states, although, the physique loses keep an eye on over antiogenesis. illnesses which are angiogensis-dependent end result whilst blood vessels both develop excessively or insufficiently.

Systems Biology and Regulatory Genomics: Joint Annual RECOMB 2005 Satellite Workshops on Systems Biology and on Regulatory Genomics, San Diego, CA, USA; December 2-4, 2005, Revised Selected Papers

This ebook constitutes the completely refereed post-proceedings of 2 joint RECOMB 2005 satellite tv for pc occasions: the 1st Annual Workshop on platforms Biology, RSB 2005 and the second one Annual Workshop on Regulatory Genomics, RRG 2005, held in San Diego, CA, united states in December 2005. The 21 revised complete papers provided have been conscientiously reviewed and chosen for inclusion within the booklet.

Extra info for Molecular Biology of G-Protein-Coupled Receptors

Sample text

1 " , , , 1 '1 I • •• • • • I , I , I ~ • I I , I I • . ~ ••• ~ ~>~ ... __ •• I ,,, , I •• I . " ' e . l c ' ••• • ~ .. .... I H ...... ~ ............... ~» •• , , , ~. , • I . . OMO • • ~~"'U> , .. " . I I . e ..... oo • • • • • • ' 4II • • • U .. ~U .. , ... >, . » » 0 •• 0 .. • • a04'O~~~~~"~~~"'~ • oaQUe • • » •••••• "''''''' • ... ~ .... ~. • •• a"' ...... > • • • • • • • • .. A .... O»»>M ...... AA ...... > .... ~ ..... ~ . . . . ~~~ • • • • ~ • • • • ~ • • ~_OOOO O • • • • ~ •• ....

C. Findlay activity from antagonists. J Bioi Chem 264:16470-16477 Strathmann M, Simon MI (1990): G-protein diversity-a distinct class of a-subunits is present in vertebrates and invertebrates. Proc Natl A cad Sci USA 87:9113-9117 Stubbs GW, Smith HG, Litman BJ (1976): Alkyl glucosides as effective solubilizing agents for bovine rhodopsin. A comparison with several commonly used detergents. Biochim Biophys Acta 426:46-56 Takao M, Yasui A, Tokunaga F (1988): Isolation and sequence determination of the chicken rhodopsin gene.

Oc~O''''· ............... ' ........................... »»> ......... 0 . . . . . . . . . UO~. ee • • e ... "'ococeee ........ > R~ M... >WH~»"" .... > ... > ...... ~. O . . . C • • • • • • • • • C' ,> ••••• , .. Q' • • >Q> .... ~. t ... •• >C ...... U ... _»U ... ~~ . . • • C .. _OQUUUOOUUU O_ .. O . . . • 40 ... U ..... ••................... _» ................. ~~~~~~~ ............. > ... ~ ......... • • "U~ ......... ••••••••• • • 'u • • • • • • " .. "",.... > ... ' ......

Download PDF sample

Rated 4.49 of 5 – based on 20 votes