Molluscs: From Chemo-ecological Study to Biotechnological by Guido Cimino (Editor), Margherita Gavagnin (Editor)

By Guido Cimino (Editor), Margherita Gavagnin (Editor)

This is often the 1st publication on molluscs as assets for pharmaceutical medications. Marine molluscs are very promising applicants for a variety of biotechnological purposes. for instance, they own analgesic medicinal drugs stronger than morphine and extremely powerful anticancer brokers. overseas specialists supply insurance of the main stimulating themes with regards to molluscs. this data in their background and present reports opens the door to the long run.

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Balkema, Rotterdam, pp. 459–472 Cimino G, De Rosa S, De Stefano S, Morrone R, Sodano G (1985) The chemical defense of nudibranch molluscs. Structure, biosynthetic origin and defensive properties of terpenoids from the dorid nudibranch Dendrodoris grandiflora. Tetrahedron 41:1093–1100 Cimino G, Gavagnin M, Sodano G, Puliti R, Mattia CA, Mazzarella L (1988) Verrucosin-A and -B, ichthyotoxic diterpenoic acid glycerides with a new carbon skeleton from the dorid nudibranch Doris verrucosa. Tetrahedron 44:2301–2310 Molluscan Natural Products as Biological Models 17 Cimino G, Passeggio A, Sodano G, Spinella A, Villani G (1991a) Alarm pheromones from the Mediterranean opisthobranch Haminoea navicula.

Therefore, related shellfish poisons may also be biosynthesized by marine microorganisms. Shellfish poisons and related compounds have been well represented, with many fine reviews (Kuramoto et al. 1999, 2003, 2004; Brett 2003; Ciminiello et al. 2003; Ciminiello and Fattorusso 2004; Jeffery et al. 2004; Suenaga 2004; Kita and Uemura 2005). In our ongoing search for bioactive metabolites from marine organisms, novel shellfish poisons such as pinnatoxins, pteriatoxins, pinnamine, and turbotoxins have been isolated.

This biosynthetic proposal entails an intramolecular Diels–Alder reaction to construct a G-ring as well as the macrocycle, followed by imine formation to establish a 6,7-spiro-ring system. Due to the structural similarity of the imine moiety adjacent to the spirocyclic core, other macrocyclic imines represented by pinnatoxin may also be biosynthesized via the same intramolecular Diels–Alder reaction. Recently, Kishi’s group achieved the total synthesis of 1 and ent-1, utilizing a biomimetic intramolecular Diels–Alder reaction (Scheme 2; McCauley et al.

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