Myocardial Tissue Engineering by Roberto Gaetani, Pieter A. F. Doevendans, Elisa Messina

By Roberto Gaetani, Pieter A. F. Doevendans, Elisa Messina (auth.), Aldo R. Boccaccini, Sian E. Harding (eds.)

Myocardial tissue engineering (MTE), a technique that makes use of fabrics or material/cell constructs to extend sufferers’ lifestyles after cardiac harm through assisting or restoring center functionality, is always enhancing. universal MTE recommendations contain an engineered ‘vehicle’, that could be a porous scaffold or a dense substrate or patch, made up of both man-made or natural polymeric fabrics. The functionality of the substrate is to help transportation of cells into the diseased zone of the guts and aid their integration. This e-book, which incorporates chapters written by way of top specialists in MTE, supplies a whole research of the world and offers the most recent advances within the box. The chapters disguise all correct facets of MTE suggestions, together with phone resources, particular TE concepts and biomaterials used. many various cellphone forms were recommended for mobile remedy within the framework of MTE, together with autologous bone marrow-derived or cardiac progenitors, in addition to embryonic or brought on pluripotent stem cells, each one having their specific merits and downsides. The publication additionally considers a whole variety of biomaterials, studying various elements in their program in MTE, equivalent to biocompatibility with cardiac cells, mechanical strength and compatibility with the mechanical homes of the local myocardium in addition to degradation behaviour in vivo and in vitro. even though loads of examine is being performed within the box, this booklet additionally addresses many questions that also stay unanswered and highlights these parts within which additional learn efforts are required. The publication also will provide an perception into medical trials and attainable novel cellphone assets for telephone remedy in MTE.

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Heart Surg. Forum. 6(2), E20–E26 (2003) 91. : Extracellular matrix scaffold for cardiac repair. Circulation 112(Suppl 9), I135–I143 (2005) 92. : Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function. Circulation 112(Suppl 9), I144–I149 (2005) 93. : The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium. Cell Transpl. (15 Suppl 1), S29–S40 (2006) 26 R. Gaetani et al. 94. : Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation.

P. D. Nardo (&) Á M. Minieri Á A. Tirella Á G. it P. D. Nardo Á M. Minieri Á G. Forte Istituto Nazionale per le Ricerche Cardiovascolari (INRC), Bologna, Italy P. D. Nardo Á M. Minieri Á G. Forte Japanese-Italian Tissue Engineering Laboratory (JITEL), Tokyo Women’s Medical University-Waseda University Joint Institution for Advanced Biomedical Sciences (TWIns), Tokyo, Japan A. Tirella Á A. Ahluwalia Centro Interdipartimentale di Ricerca ‘‘E. 1007/8415_2010_58 Ó Springer-Verlag Berlin Heidelberg 2011 Published Online: 21 January 2011 29 30 P.

Combinations of synthetic and natural materials were tested for cell culture and tissue engineering. Alginate was combined with PLGA microspheres, carrying alginate lysate, in order to enhance and control the biodegradation rate [115]. Other applications combined collagen material with polycaprolactone for growth of fibroblasts and keratinocytes [116]. In the same way, polycaprolactone was combined with chitosane [117], fibrin [118], fibronectin [118] and gelatin [119]. Another model was reported by Chen et al.

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