Nitric oxide and infection by Ferric C. Fang

By Ferric C. Fang

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It is perhaps not coincidental that Listeria monocytogenes is an intracellular pathogen, as are so many of the pathogens for which NO appears to play an antimicrobial role (see Chapter 12, Table 2). This may relate to the abundance of NO-scavenging substances in the extracellular environment. Notably, NOS inhibition has a dramatic effect on the course of infection in primary listeriosis, but no impact in immune animals, emphasizing the role of NO in innate nonspecific immunity. AN OVERVIEW OF NO IN INFECTION 9 5.

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