Ovarian Toxicology (2nd Edition)

This present day, we're uncovered to a growing number of chemical substances within the atmosphere and there's a turning out to be understanding of the consequences of those chemical substances at the ovaries. Infertility as a result of environmental exposures is probably not visible till the reproductive existence span is waning. As such, the opportunity of xenobiotic-induced infertility should be greater understood.

In contemporary years, study into chemical compounds that experience the capability to reason early menopause by means of destroying pre-antral ovarian follicles is gaining better appreciation. Ovarian Toxicology, moment version represents a compilation of chapters ready through researchers who've considerably contributed to our realizing of the impression of xenobiotics and environmental elements on ovarian functionality. the second one variation considerably updates newly investigated ovotoxicants in addition to better mechanistic insights that experience emerged because the first edition.

Topics include:

Ovarian body structure and the metabolism of xenobiotics
The impact of insecticides, heavy metals, phthalates, BPA, and cigarette smoking at the ovaries
Ovarian melanoma, together with endocrine results and new views on chemoresistance
Epidemiology and human healthiness possibility review for environmental chemical compounds and pharmaceuticals
The first e-book to concentration particularly on ovarian toxicology, this source is perfect for scientists in academia, regulatory enterprises, and who would get advantages from a survey of the influence of xenobiotic chemical compounds on ovarian function.

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Additional info for Ovarian Toxicology (2nd Edition)

Example text

Dunn RT 2nd, Klaassen CD. 1998. Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug Metab Dispos 26:598–604. Environmental Protection Agency. 1985. Health Assessment Document for Tricholoroethylene. Final Report. EPA/600/8-82/006F. Washington, DC: Environmental Protection Agency, Office of Health and Environmental Assessment. Fernandez SM, Keating AF, Christian PJ et al. 2008. Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats.

1995. Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity. Drug Metab Disp 23:846–853. Liu K, Rajareddy S, Liu L et al. 2006. Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. Dev Biol 299:1–11. Lopez SG, Luderer U. 2004. Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis. Free Rad Biol Med 36:1366–1377.

2004). , 2009). , 2004). , 2003), which may also contribute to CDDP-induced ovarian damage. , 2004). CPA is an antineoplastic prodrug that acts as an alkylating agent to treat, alone or in combination, a variety of cancers and autoimmune disorders. CPA was FDA approved in 1959 and is also known by its brand names: Cytoxan, Clafen, and Neosar. , 1991). Infertility is particularly concerning for females because CPA destroys primordial follicles (Plowchalk and Mattison, 1991). In a similar manner as that of DMBA, CPA is inactive until it is metabolized, primarily by hepatic CYP enzymes, inducing production of a number of active and inactive metabolites.

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