By Xuejun Zhong, Bing Hao, Michael K. Chan (auth.), Stephen T. Crews (eds.)
PAS proteins regulate a number of physiological and developmental occasions, and span phylogeny from micro organism to guy. Bacterial and plant PAS proteins act as sensors of environmental stimuli, together with mild, oxygen, and effort status.
Not brilliant, given those roles, there's severe research of the jobs of bHLH-PAS proteins in problems with human future health together with: (1) melanoma induction, (2) melanoma progress and vascularity, (3) beginning defects, together with Down syndrome, (4) urge for food regulate and weight problems, (5) sleep rhythm problems, and (6) psychological wellbeing and fitness problems akin to social interactions and learning.
PAS proteins surround many fields of biology, and scientists who paintings in those fields (circadian rhythms, oxygen rules, toxin metabolism, bacterial sensors, and improvement) are an viewers, rather those that actively paintings on PAS proteins and researchers drawn to transcriptional keep an eye on, sign transduction, and evolution.
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Additional info for PAS Proteins: Regulators and Sensors of Development and Physiology
Signaling via physical interaction between PAS domains and a signaling protein/domain may be a recurring paradigm in PAS domain signaling. Although the control mechanism is not completely understood, recent data suggest that the PpsR protein binds DNA after disulfide bond formation between PAS domain residue C251 (M112 Aer homologue) and amino acid C424 in the HTH motif, which is the domain known to be directly responsible for DNA binding (64). The oxidized conformation binds to palindromic sequences of the promoters that it regulates.
Microbiol. 20:903-10. , and M. Eisenbach. 1996. Regulation of interaction between signaling protein CheY and flagellar motor during bacterial chemotaxis. Curro Top. Cell. Regul. 34:137-58. Grimshaw, C. , S. Huang, C. G. Hanstein, M. A. Strauch, D. Burbulys, L. Wang, J. A. Hoch, and 1. M. Whiteley. 1998. Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in Bacillus subtilis. Biochemistry 37: 1365-75. , and 1. A. Hoch. 2001. PAS-A domain of phosphorelay sensor kinase A: a catalytic ATP-binding domain involved in the initiation of development in Bacillus subtilis.
Phosphorelay system in BvgS [modified from (2)]. BvgS has an N-terminal periplasmic domain linked by a transmembrane region to a cytoplasmic PAS domain, transmitter, receiver, and histidine phosphotransfer domains (2, 40, 41) The BvgA protein is a 23-kDa cytoplasmic response regulator which has a receiver domain and a Cterminal DNA-binding domain (127). Transfer of the phosphoryl group from BvgS to BvgA increases the affinity of BvgA for promoters that activate the transcription of genes involved in virulence (128, 129).