By ROGER FENWICK, Yongping Bao
"… well-written and the content material is obviously awarded. … There are ample figures and tables, that are successfully categorized and accurately help the content material. …highly prompt for tutorial and particular libraries. …effectively offers present study on phytochemicals in a readable manner."- E-Streams "This landmark quantity exhibits how a ways the sphere has complex … . this significant quantity is stuffed with experiences on what the editors time period because the 'new period' within the examine of phytochemicals, within which we movement from the 'eat extra vegetable and fruit' admonition to extra exact details at the biology, molecular biology, regulatory functionality, and position in human healthiness of phytochemicals. … All employees in phytochemicals should still get themselves a duplicate of this important book."
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Extra resources for Phytochemicals in Health And Disease (Oxidative Stress and Disease)
Molecular Cloning: A Laboratory Manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press, 2001. 7. Eisen MB, Brown PO. Methods Enzymol 1999; 303:179–205. 8. Dong Y, Ganther HE, Stewart C, Ip C. Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Res2002; 62:708–714. 9. Chuang Y-Y E,Chen Y, Chandramouli GVR, Cook JA, Coffin D, Tsai M-H, DeGraff W, Yan H, Zhao S, Russo A, Liu ET, Mitchell JB. Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.
Curr Opin Chem Biol 2003; 7:55–63. 26. Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 2002; 1:153–161. 27. Moore JB, Blanchard RK, McCormack WT, Cousins RJ. cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lympohcyte population change. J Nutr 2001; 131:3189–3196. 2 Methods to Study Bioavailability of Phytochemicals Birgit Holst and Gary Williamson Nestlé Research Center, Nestec, Lausanne, Switzerland I.
After food processing, mastication is the first step that is likely to cause cell disruption and release of the phytochemical glycoside. , the glucosinolates, are not biologically active per se but serve as precursors for a range of bioactive compounds. Depending on the degree of cell disruption, glucosinolates are released and hydrolyzed by an enzyme, myrosinase, that co-occurs with its substrate. In the intact plant material, both enzyme and substrate are compartmentalized at cellular level; however, once cellular integrity is disrupted, enzyme and substrate interact, leading to formation of the aglycon—generally the active component.