Polymer Nanoparticles for Nanomedicines: A Guide for their by Christine Vauthier, Gilles Ponchel

By Christine Vauthier, Gilles Ponchel

This quantity serves as a worthy instruction manual for the advance of nanomedicines made from polymer nanoparticles since it presents researchers, scholars, and marketers with the entire fabric essential to commence their very own tasks during this box. Readers will locate protocols to arrange polymer nanoparticles utilizing assorted equipment, when you consider that those are in line with the range of stories that specialists come across within the box. moreover, complicated issues resembling, the optimum characterization of polymer nanoparticles is mentioned, in addition to useful guidance on how you can formulate polymer nanoparticles into nanomedicines, and the way to switch the houses of nanoparticles to provide them the several functionalities required to develop into an effective nanomedicine for various scientific purposes. The booklet additionally discusses the interpretation of know-how from study to perform, contemplating features concerning industrialization of practise and features of regulatory and medical development.

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Additional info for Polymer Nanoparticles for Nanomedicines: A Guide for their Design, Preparation and Development

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For instance, those based on self-assembly of polymers are progressing as they can be applied to assemble a family of polymers in which each is bearing a different functionality to be included into one nanoparticle (De Miguel et al. 2015; Bao et al. 2013). Another suitable method that offers possibilities to integrate different functionality in a single nanoparticle is based on the superimposition of polymer layers forming the final nanoparticles layer-by-layer (Caruso 2001; Bao et al. 2013; Yan et al.

Adv Drug Del Rev 47:83–97 Kabanov AV, Vinogradov SV (2009) Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed Engl 48:5418–5429. 200900441 Karnik R, Gu F, Pamela Basto P, Cannizzaro C, Dean L, Kyei-Manu W, Langer R, Farokhzad OC (2008) Microfluidic platform for controlled synthesis of polymeric nanoparticles. Nano Lett 8:2906–2912. 1021/nl801736q Kataoka K, Harada A, Nagasaki Y (2001) Block copolymer micelles for drug delivery: design, characterization and biological significance.

In order to explain this contradiction, Budhian et al. (2007) and Arica and Lamprecht (2005) proposed the presence of two competing effects at high PVA concentrations: an enhanced interfacial stabilization that caused a size decrease and an increased viscosity of the aqueous phase which led to a less favorable mixing efficiency and thus, to a size increase. The concentration of PVA at which one effect starts dominating over the other depends on the system and processing parameters. For PLGA nanoparticles, the size first decreased due to better stabilization and then increased at higher PVA concentrations due to high aqueous phase viscosity (Arica and Lamprecht 2005; Budhian et al.

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