Presenting Toxicology Results by Gerhard J. Nohynek

By Gerhard J. Nohynek

Written in this kind of means as to make it available to toxicologists who would not have English as a primary language, this e-book specializes in comparing, examining and reporting result of regulatory toxicology stories.

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A well-structured report will help the reviewer to understand and accept the authors conclusions regarding the safety of a test compound. The structure of scientific documents is discussed below. 1 The ‘IMRAD’ Structure Almost all scientific publications and reports use the “IMRAD” structure. IMRAD is the acronym for Introduction, Methods, Results, and Discussion/Conclusion, and is the most common labeling of the components of a scientific report. , 1979a). A scientific report following IMRAD guidelines consists of the following components: 1 Title 2 Abstract/Synopsis: Summarizes the principal elements of the study.

31 Presenting toxicology results continued The animals were weighed and examined daily for clinical signs. Food consumption was determined daily. The number and body weight of pups were recorded and their physical and functional development and behavior were evaluated on standardized litters. On day 21 post-partum, maternal animals were sacrificed and necropsied. Developmental parameters evaluated in the pups of the F1 generation included pinna detachment (from day 4 post-partum), incisor eruption (from day 11), eye opening (from day 15), testes descent (day 25) and vaginal opening (day 37).

These were observed in both males and females; they were marked at 200 mg/kg/day and mild at 45 mg/kg/day. Administration of 200 mg/kg/day resulted in a lower food consumption (males: –5%; females: –8%), associated with lower terminal mean body weight (males: –13%; females: –16%), relative to controls. Terminal biochemical and hematologic parameters were similar in all groups. An increase in liver weights (males: +28%; females: +18%, versus controls), associated with centrilobular hypertrophy (more marked in males) was observed in all animals at 200 mg/kg/day.

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