Protein Dimerization and Oligomerization in Biology by Jacqueline M. Matthews

By Jacqueline M. Matthews

This quantity has a robust specialise in homo-oligomerization, that's strangely universal. even if, protein functionality is so frequently associated with either homo- and hetero-oligomerization and lots of heterologous interactions most probably developed from homologous interplay, so this quantity additionally covers many elements of hetero-oligomerization.

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For any given species the volume fraction of the internal bead volume that is accessible is termed the partition coefficient mp (see ref. 1). Smaller proteins have a larger value of mp and require a greater volume of buffer to pass through the column before they are eluted. 4 The molecular weight for the protein of interest can then be determined from this standard curve. Unfortunately, for nonspherical species mp is a poor predictor of M. However, SEC can provide M and molecular shape information by combination with, for example, sedimentation coefficient2 or in-line light scattering measurements.

Yu X, Sharma KD, Takahashi T et al. Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling. Mol Biol Cell 2002; 13:2547-2557. 41. Mukai Y, Nakamura T, Yoshikawa M et al. Solution of the structure of the TNF-TNFR2 complex. Sci Signal 2010; 3:ra83-. 42. Chan FK, Chun HJ, Zheng L et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 2000; 288:2351-2354. 43. Clancy L, Mruk K, Archer K et al.

Smaller proteins have a larger value of mp and require a greater volume of buffer to pass through the column before they are eluted. 4 The molecular weight for the protein of interest can then be determined from this standard curve. Unfortunately, for nonspherical species mp is a poor predictor of M. However, SEC can provide M and molecular shape information by combination with, for example, sedimentation coefficient2 or in-line light scattering measurements. For interacting systems the appearance of an SEC elution profile depends on the rate of exchange between monomer and oligomer states.

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