Systems Biology of Tumor Dormancy by Nava Almog PhD (auth.), Heiko Enderling, Nava Almog, Lynn

By Nava Almog PhD (auth.), Heiko Enderling, Nava Almog, Lynn Hlatky (eds.)

This quantity relies at the Workshop on platforms Biology of Tumor Dormancy assembly, held July twenty fifth to July twenty eighth, 2011. the 1st annual CCSB workshop introduced jointly biologists, clinicians, mathematicians, and laptop scientists to debate numerous elements of tumor dormancy and increase novel mathematical/computational types with the keynote audio system. particular issues incorporated the angiogenic swap, immune process interactions, melanoma stem cells and signaling.

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J Natl Cancer Inst 93(14):1075–1081 39. Hlatky L, Hahnfeldt P, Folkman J (2002) Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn’t tell us. J Natl Cancer Inst 94(12):883–893 40. Naumov GN, Bender E, Zurakowski D, Kang SY, Sampson D, Flynn E et al (2006) A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J Natl Cancer Inst 98(5):316–325 41. Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285(21): 1182–1186 42.

These fits included a final one to the full cohort (V8 = 215,600 mm3), which contained all tumor measurements (the largest tumor size measured was 215,600 mm3). This last fit was not redundant to the original that allowed us to solve for K, a, and tij in the first place, because the full cohort fit was done with explicit knowledge of the tij, just as with the other cohort fits. Times corresponding to the arbitrary Vm values were inferred from the full-cohort fit to 32 P. Hahnfeldt Eq. 13), and plotted against the ratio of Km/Vm surmised from each of the cohort fits m = 1, …, 8.

Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE (2007) Transcriptional network governing the angiogenic switch in human pancreatic cancer. Proc Natl Acad Sci USA 104(31):12890–12895 29. Indraccolo S, Favaro E, Amadori A (2006) Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis. Cell Cycle 5(16):1751–1755 30. Coffey JC, Wang JH, Smith MJ, Boucher-Hayes D, Cotter TG, Redmond HP (2003) Excisional surgery for cancer cure: therapy at a cost.

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