Target Discovery and Validation Reviews and Protocols, Vol by Mouldy, Ed. Sioud

By Mouldy, Ed. Sioud

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Sci. USA 87, 4207–4211. 25. Hung, M. -C. and Lau, Y. -K. (1999) Basic science of HER-2/neu: A Review. Semin. Oncol. 26, 51–59. 26. Amundadottir, L. T. and Leder, P. (1998) Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene 16, 737–746. 27. , and Raymond, E. (2005) mTOR-targeted therapy of cancer with rapamycin derivatives. Ann. Oncol. 16, 525–537. 28. Mass, R. D. (2004) The HER receptor family: a rich target for therapeutic development.

Sebolt-Leopold, J. S. (2000) Development of anticancer drugs targeting the MAP kinase pathway. Oncogene 19, 6594–6599. 47. Dudley, D. , Decker, S. , Bridges, A. , and Saltiel, A. R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 7686–7689. 48. Sebolt-Leopold, J. , Dudley, D. , et al. (1999) Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med. 5, 810–816. 49. Schaeffer, H. J. and Weber, M. J. (1999) Mitogen-activated protein kinases: specific messages from ubiquitous messengers.

Nature 411, 375–379. 78. , et al. (2004) Colony-stimulating factor-1 blockage by antisense oligonucleotides and small-interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Caner Res. 64, 5378–5384. 2 DNA Methylation and Histone Modifications in Patients With Cancer Potential Prognostic and Therapeutic Targets Michel Herranz and Manel Esteller Summary Epigenetics, a combination of DNA modifications, chromatin organization, and variations in its associated proteins, configure a new entity that regulates gene expression throughout methylation, acetylation, and chromatin remodeling.

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