The Herpesviruses: Volume 2 by Fred Rapp (auth.), Bernard Roizman (eds.)

By Fred Rapp (auth.), Bernard Roizman (eds.)

The first quantity of the sequence entitled entire Virology was once pub­ lished in 1974 and the final is but to seem. We famous in 1974 that virology as a self-discipline has undergone its descriptive and phenomenological stages and was once becoming a member of the molecular biology revolution. The volumes released up to now have been intended to function an in-depth research and conventional reference of the evolving box of virology. We felt that viruses as organic entities needed to be thought of within the context of the wider fields of mo­ lecular and mobile biology. actually, we felt then, and believe much more strongly now, that viruses, being less complicated organic types, may perhaps function priceless probes for investigating the biology of the way more advanced host mobile. through the decade-long compilation of a chain of books like finished Virology, a number of the insurance will evidently now not stay updated. the standard therapy to this point of technological know-how publishing is to supply a moment version. besides the fact that, in view of the big bring up in wisdom approximately viruses, we felt new strategy used to be wanted in masking virology within the Eighties and Nineteen Nineties. hence we determined to desert the slightly arbitrary subgrouping of the subject material of Compre­ hensive Virology less than the titles copy, constitution and meeting, law and Genetics, extra themes, and Virus-Host Interac­ tions. as an alternative we now have geared up a brand new sequence entitled The Viruses.

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But no other proteins were detected until after the initiation of MCMV DNA synthesis when major structural proteins are made. , 52 proteins were labeled in infected cells. Of these, 29 had electrophoretic mobilities similar to those of structural virus proteins, and 8 precipitated by antisera to infected-cell antigens may be nonstructural proteins. The remaining 15 are classified as host proteins. MCMV-infected S-phase and Go-phase nuclei incorporated more [3H]-dTMP than did uninfected nuclei (Muller and Hudson, 1978).

Musiani et al. (1979) studied the histochemical properties of lEAs and suggested that these antigens are proteins with DNA-binding properties. , 1979). , two polypeptides with molecular weights of 76,000 and 82,000 daltons were detected. Polypeptides of similar molecular weights were found in immunoprecipitates of nonpermissive cells infected with HCMV. More than 40% of normal blood donors react to lEA, and reactivity to lEA correlates highly with active virus excretion. HEL cells infected with HCMV can induce a pre-early nuclear antigen (PENA) within 1 hr pj.

Hyperimmune mouse serum reduced B-cell-associated infectious centers by 74% but T-cell-associated infectious centers by only 38%. Three strains of mice were latently infected at birth with MCMV, and by adulthood, the testes of these mice contained 4-6 genome equivalents per 100 cells when tested by hybridization with mouse DNA and MCMV DNA (Dutko and Oldstone, 1979). Thus, it appears that MCMV can replicate in spermatogenic cells and is harbored in the testes during acute and latent infections.

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