The Molecular Repertoire of Adenoviruses II: Molecular by P. C. Van der Vliet (auth.), Walter Doerfler, Petra Böhm

By P. C. Van der Vliet (auth.), Walter Doerfler, Petra Böhm (eds.)

For a long time this virus method has served--and maintains to do so--to pioneer investigations at the molecular biology, biochemistry and genetics of mammalian cellphone platforms. This 3 quantity paintings provides an updated account of modern simple examine in a single of crucial experimental platforms for biochemical, mobilephone organic, genetic, virological and epidemiological investigations in mammalian molecular biology. during this, the second one of 3 volumes, the eye is became to such issues as DNA replication, recombination and integration, and post-transcriptional keep watch over. The chapters were written by way of a global crew of best specialists of their respective fields of interest.

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Cell 31: 613-623 Stow ND (1981) The infectivity of adenovirus genomes lacking DNA sequences from their left-hand termini. Nucleic Acids Res 10: 5105-5119 Stuiver MH, Van der Vliet PC (1990) The adenovirus DNA binding protein forms a multimeric protein complex with double-stranded DNA and enhances binding of nuclear factor I. J Virol 64: 379-386 Stuiver MH, Bergsma WG, Amberg AC, Van Amerongen H, Van Grondelle R, Van der Vliet PC (1992) Structural alterations of double-stranded DNA in complex with the adenovirus DNA-binding protein.

43 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 1 Introduction Over the past 20 years studies on the replication of adenovirus DNA have contributed not only to an understanding of the mechanics of adenovirus DNA replication, but have also shed light on basic processes such as the assembly of nucleoprotein complexes and virus-host interactions. This subject has been reviewed extensively (HAY and RUSSELL 1989; STILLMAN 1989; VAN DER VLIET 1990; SALAS 1991), but a number of recent findings have suggested that the time may be ripe for further evaluation of new developments in the field.

It also prevents other end-binding proteins such as the NFIV/Ku protein to enter the DNA and block replication (DE VRIES et al. 1989). Also, TP-DNA has been shown to attach tightly to the nuclear matrix throughout the course of infection (BODNAR et al. 1989; SCHAACK et al. 1990b). Matrix association may Adenovirus DNA Replication 19 localize the viral genome to particular nuclear compartments in which replication and transcription factors could be concentrated, as shown by the appearance of replication foci in infected cells.

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