Translational Control of Gene Expression by Nahum Sonberg

By Nahum Sonberg

Because the 1996 booklet of Translational keep an eye on, there was clean curiosity in protein synthesis and popularity of the foremost function of translational keep an eye on mechanisms in regulating gene expression. This new monograph updates and expands the scope of the sooner booklet however it additionally takes a clean examine the sector. In a brand new layout, the 1st 8 chapters offer huge overviews, whereas all of the extra twenty-eight has a spotlight on a learn subject of extra particular curiosity. the result's a completely updated account of initiation, elongation, and termination of translation, keep watch over mechanisms in improvement based on extracellular stimuli, and the consequences at the translational equipment of virus an infection and affliction. This ebook is vital studying for college kids getting into the sphere and a useful source for investigators of gene expression and its regulate.

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Also, proteins exhibiting homology with eIF4G (p97/DAP5/NAT1 and Paip1) have been described (Chapter 6). These proteins modulate translation most likely via their interaction with eIF4Gbinding proteins. Similarly, eIF2 activity may be modulated by an accessory protein, p67, which binds to eIF2 and prevents its phosphorylation by eIF2 kinases (Chapter 5). Elongation Factors Elongation rates are also modulated by phosphorylation, particularly through the activity of the translation elongation factor eEF2.

4 kcal/mole (de Smit and van Duin 1990). There is no in vivo evidence that bacteria employ RNA helicases to remove mRNA secondary structure at initiation sites. However, factor W2, a bacterial homolog of eIF4A (the prototypical RNA helicase of eukaryotes), stimulates in vitro the translation of a cistron whose ribosome-binding site is masked by secondary structure (Lu et al. 1999). How W2 might specifically recognize ribosome-binding sites and thereby stimulate translation is not easily explained.

Each of these steps is known to be regulated in one or another biological system. Yet, two of the steps in this grand scheme, transcription and translation, are especially critical for the cell. Both are biosynthetic steps in which the cell makes large investments of energy. Consequently, both are steps at which the cell’s expenditure of resources is checked. Indeed, transcription is subject to a multitude of controls. So, why control translation, too? And where and when is this option exercised?

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