Vascular Innervation and Receptor Mechanisms. New by Rolf Uddman

By Rolf Uddman

In the past decade our knowing of the complicity of mechanisms controlling movement has elevated. This paintings presents an summary of vascular innervation and receptor mechanisms, specially the involvement of neurotransmithers, endothelium, and physiological keep an eye on by means of neuropeptides. additionally tested is the function of neuropeptides. additionally tested is the function of neuropeptidergic innervation in vascular issues and new techniques to attainable destiny therapeutics.

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Vascular Innervation and Receptor Mechanisms. New Perspectives

In past times decade our knowing of the complicity of mechanisms controlling flow has elevated. This paintings presents an summary of vascular innervation and receptor mechanisms, in particular the involvement of neurotransmithers, endothelium, and physiological regulate through neuropeptides. additionally tested is the function of neuropeptides.

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80, 276-288. , Haven, A. , and Burnstock, G. (1986). Perivascular noradrenergic and peptidecontaining nerves show different patterns of change during development and ageing in the guinea-pig. J. Auton. Nerv. Syst. 16, 109-126. , and Seylaz, J. (1988). Ultrastructural changes in the cerebral artery wall induced by long-term sympathetic denervation. Blood Vessels 25, 122-143. Docherty, J. R. (1986). Aging and the cardiovascular system. J. Auton. Pharmac. 6, 77-84. , and Gero, J. (1974). Postnatal development of the sympathetic innervation in skeletal muscles of the dog.

A), the perivascular terminal nerve fibers of these neurons rarely exhibit obvious increases in noradrenaline levels in old age, and decreases in noradrenergic indices are more common (Cowen and Burnstock, 1986). Neurotransmitter expression in autonomic nerves to blood vessels varies during aging in a regionally specific way. , 1986). , 1987), while in this laboratory, increases of noradrenergic nerve density on the tail vein of aged rats have been observed (Andrews and Cowen, unpublished data).

1977). Development of neuroeffector mechanisms in the carotid artery of the fetal lamb. Blood Vessels 14, 12-24. Thoenen, H. (1991). The changing scene of neurotrophic factors. TINS 14, 165-170. -A. (1980). Physiology of nerve growth factor. PhysiolRev. 60, 1284-1335. 40 T . , Angeletti, P. , and Kettler, R. (1971). Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine-B-hydroxylase in the rat superior cervical ganglia. Proc. Nati. Acad. Sci. A. 68, 1598-1602. Thompson, R.

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