Vasopressin: Principles and Properties by J. F. Morris, D. B. Chapman, H. W. Sokol (auth.), Don

By J. F. Morris, D. B. Chapman, H. W. Sokol (auth.), Don Marshall Gash, Gerard J. Boer (eds.)

The inspiration for Vasopressin: rules and houses originated throughout the sum­ mer of 1983. From reviewing the wealthy and various literature on vasopressin, it turned obtrusive that the fast developments during this box made it tough to syn­ thesize the data accumulated from divergent medical disciplines right into a coherent view of the organic function of vasopressin. We perceived the necessity for a chain of severe experiences delineating this contemporary growth. during the last decade, significant advances were made in stories of the anatomy, body structure, phar­ macology, molecular biology, and behavioral actions of vasopressin. this can be, in no small degree, because of the discovering that vasopressin can not be looked completely as a neurohypophysial hormone. Our current wisdom is that vasopressin is synthesized in additionally has an axonal messenger position within the worried approach and of the mind, even supposing the services of vasopressin in those periph­ websites outdoors of vasopressin eral websites aren't good understood. which will organize an summary focusing on fresh reports in vertebrates, authors have been chosen in keeping with their services and requested to study their learn sector, together with the paintings from different laboratories. It used to be our reason to supply an up-to-date definitive reference which might supplement and expand such previous texts as Neurohypophysial Hor­ mones and related Polypeptides (Handbook of Experimental Pharmacology, Vol­ ume XXIII, 1968) and The Pituitary Gland and Its Neuroendocrine keep watch over (Handbook of body structure, part 7: quantity IV, 1974).

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13), and as swellings that do not contact the basement membrane and that generally lack microvesicles (Fig. 14) (Morris, 1976b). Morphological and physiological experiments have demonstrated that the endings are functionally defined as specialized sites of hormone release, whereas swellings are the main sites of hormone storage. Thus, for example, when hormone release is stimulated in vitro, NSVs are depleted from ending but not swelling profiles (Nordmann and Morris, 1976; Morris and Nordmann, 1980).

A pronounced reduction in the maturity of NSVs in the perikarya occurs in rats drinking saline solution for 3 days (Morris and Dyball, 1974). Since the rate of axonal transport does not alter with the secretory state (Norstrom and Sjostrand, 1972a,b), this finding suggests that, in unstimulated animals, a proportion of NSVs are normally stored in the perikarya. 5), large numbers of NSV accumulate, mostly in the periphery of the cells. In the hypothalamus, axonal dilatations are all of the swelling type, whereas in the neural lobe of unstimulated animals about 60% ofNSV are located in swellings-30% in endings and 10% in undilated axons (Morris, 1976b; Nordmann, 1977).

Nerve ending in the neurohypophysis of a rat. Note the contact zone with the basement membrane (8M), along which the membrane shows focal densities (arrowheads). Electron-dense neurosecretroy vesicles (NSV) are abundant; microvesicles (MV) lie clustered centrally within the nerve ending, and are also scattered. A larger vacuole, of the size of a neurosecretory vesicle (V), is seen. Scale bar: 200 nm. FIGURE 32 J. F. MORRIS ET AL. FIGURE 14. Low-power view of the neurohypophysis of a rat. A pituicyte (P) lies centrally within the lobule and sends processes (fine arrows) toward the perivascular basement membrane.

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